In Molecular biology, DNA replication is the biological procedure of producing two identical replicas of DNA from one unique DNA molecule. This procedure happens in every single living being and is the reason for biological inheritance. The cell has the specific property of division, which makes replication of DNA essential. DNA is comprised of a twofold helix of two integral strands. During replication, these strands are isolated. Each strand of the DNA molecule then serves as a template for the production of its counterpart, a process referred to as semiconservative replication. Because of semi-conservative replication, the new helix will be made out of an original DNA strand as well as newly synthesized DNA strand. Cellular proof reading and error checking components mechanisms ensure near perfect fidelity for DNA replication. In a cell, DNA replication starts at particular areas or origins of replication in the genome. Unwinding of DNA at the origin and synthesis of new strands, accommodated by an enzyme known as helicase, results in replication forks developing bi-directionally from the birthplace. Various proteins are related with the replication fork to help in the initiation and continuation of DNA synthesis. Most remarkably, DNA polymerase synthesizes the new strands by including nucleotides that complement every strand. DNA replication happens during the S-phase of interphase.
Biochemistry and Modern Applications is a peer reviewed Journal, with rapid publication process. The topics like DNA polymerases, Heterochromatin, Ribosome, Non-coding DNA, Cell biology, Metabolism, Nutritional Biochemistry, Medicinal Biochemistry and Hormonal Biochemistry are studied. This is not just limited to above areas. The knowledge related to different biomolecules and their mechanisms can be studied in the journal of Biochemistry and modern applications. This journal provides an open access platform for the young scientists and researchers to share their valuable information regarding the biomolecules and their mechanism.