In biology, a mutation is the permanent modification of the nucleotide sequencing of the genome of a life form, virus or extra chromosomal DNA or other hereditary elements. Mutations result from mistakes during DNA replication (particularly during meiosis) or different sorts of damages to DNA, (for example, might be caused by introduction to radiation or cancer-causing agents), which then may undergo error-prone repair (particularly micro homology-mediated end joining), or cause an error during different repairs or else may cause a error during replication (translesion synthesis). Mutations may likewise result from insertion or deletion of portions of DNA because of mobile genetic elements. Mutations could possibly deliver noticeable changes in the detectable attributes (phenotype) of a living being. Mutations have an impact in both normal and abnormal natural procedures including: evolution, malignant growth, and the improvement of the immune system, including junctional diversity. The genomes of RNA infections depend on RNA instead of DNA. The RNA viral genome can be twofold stranded (as in DNA) or single stranded. In a portion of these infections, (for example, the single stranded Human Immunodeficiency Virus) replication occurs rapidly and there are no mechanisms to check the genome for precision. Due to the damaging effects that mutations can have on genes, organisms have mechanisms such as, DNA repair to avoid or correct mutations by by reverting the mutated sequence back to its original state..
Biochemistry and Modern Applications is a peer reviewed Journal, with rapid publication process. The topics like DNA polymerases, Heterochromatin, Ribosome, Non-coding DNA, Cell biology, Metabolism, Nutritional Biochemistry, Medicinal Biochemistry and Hormonal Biochemistry are studied. This is not just limited to above areas. The knowledge related to different biomolecules and their mechanisms can be studied in the journal of Biochemistry and modern applications. This journal provides an open access platform for the young scientists and researchers to share their valuable information regarding the biomolecules and their mechanism.