Nephrotic syndrome may be an assortment of symptoms thanks to excretory organ injury. This includes macromolecule within the low blood simple protein levels, high blood lipids, and vital swelling. Different symptoms might embody weight gain, feeling tired and foamy urine. Complications might embody blood clots, infections, and high vital sign. Causes embody variety of excretory organ diseases like focal segmental glomerulosclerosis, membranous uropathy, and smallest modification illness. It should conjointly occur as a complication of polygenic disorder. The underlying mechanism generally involves injury to the glomeruli of the excretory organ. Diagnosis is typically based on urine testing and sometimes a kidney biopsy. It differs from nephritic syndrome in this there are not any red blood cells in the urine. Treatment is directed at the underlying cause. Different efforts embody managing high vital sign, high blood sterol, and infection risk. An occasional salt diet and limiting fluids is usually counseled. Concerning five per a 100, 000 individuals area unit affected per annum. The same old underlying cause varies between youngsters and adults.