A prescription drug is also prescription medication or prescription medicine. It is a pharmaceutical drug that legally requires a medical prescription to be dispensed. In contrast, over-the-counter drugs can be obtained without a prescription. Rx (℞) is often used as a short form for prescription drug. Prescription drugs are often strong medications, which is why they require a prescription in the first place. Every medication has some risk for harmful effects, sometimes serious ones. Doctors consider the potential benefits and risks to each patient before prescribing medications and take into account a lot of different factors like Personal information, Form and dose, Side effects. Prescription and over-the-counter drugs are the most commonly misused substances.The aim of the Pharmacovigilance and Pharmacoepidemiology Journal is to publish high quality research in the discipline of Pharmacovigilance by providing encouragement for editors, reviewers, authors, and readers to have an uninterrupted scientific communication.