Vaccines are safety and effective. As a result of vaccines square measure given to many healthy individuals as well as kids to stop serious diseases, they are control to terribly high safety standards. The security and d effectiveness of vaccines are beneath constant study. As a result of vaccines square measure designed to tend habitually throughout well-child care visits, they have to be terribly safe. Safety testing begins as shortly as a replacement immunizing agent is contemplated, continues till its commissioned, and is monitored indefinitely once licensure. The primary definition of the word safe is harmless. This definition would imply that any negative consequence of an immunizing agent would create the immunizing agent unsafe. Victimization this definition, no immunizing agent is 100% safe. The majority vaccines will cause pain, redness or tenderness at the positioning of injection. And a few vaccines cause additional severe aspect effects. As an example, the initial respiratory illness immunizing agent might cause persistent, inconsolable crying, high fever or seizures related to fever. Though none of those severe symptoms resulted in permanent harm, they might be quite scary to oldsters. Pharmacovigilance and Pharmacoepidemiology Journal offer a stage in Pharmacoepidemiology Researches and related subjects. Journal accepts leading forefront original research papers, review manuscripts, case reports and commentary in the field. Our target audience, readers and contributors are worldwide.