Peripheral Insulin Resistance
Peripheral Insulin Resistance (PIR) is considered as a pathological condition in which cells fail to respond normally to the hormone insulin. Simply stated, Insulin resistance is a condition in which multiple tissues in the human body become resistant to the effects of insulin. It typically develops with obesity and the onset of type 2 diabetes in which circulating insulin levels are frequently increased. Insulin resistance is caused by lipid overload, resulting from either a high fat diet or insufficient fat burning through movement. A high intake of dietary fat causes lipid overload and insulin resistance in the muscle and liver. Sucrose (white table sugar) also increases liver insulin resistance