Five-membered rings
The parent aromatic compounds of this family are pyrrole, furan, and thiophene. The saturated derivatives are known as pyrrolidine, tetrahydrofuran, and thiophane. Pyrrole derivatives are widespread in the living world; these compounds are found among the alkaloids, a large class of alkaline organic nitrogen compounds produced primarily by plants. Commercial preparation of furan proceeds by way of the aldehyde, furfural, which in turn is generated from pentose containing raw materials like corncobs. General preparations of pyrrole, furan and thiophene from 1,4-dicarbonyl compounds is namely known as the Paal-Knorr synthesis. Dipolar cycloaddition reactions are most often leading to the formation of complex five-membered heterocycles.
Journal of heterocyclics is a scholarly journal that aims to publish most complete and reliable source of information on the findings and current developments in the form of original Research, Review, Opinion articles, Case reports, Mini review, and Short commentaries. Journal of heterocyclics is an scholarly open access maintaining high standards of scientific excellence and its editorial board ensures rapid peer review process.
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