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Journal of Obesity and Diabetes (ISSN: 2638-812X)

Review Article

Both Fasting Blood Glucose (FBG) and A1c Drop in Less than One Month after Starting Lysulin Supplementation

John F Burd

DOI Number:


Published on October, 2019


When a diabetes treatment is changed, patients are eager to see their FBG and A1c changes as a result on the new treatment.  We examined these changes in 20 subjects with Type 2 diabetes for 1 week prior to starting Lysulin and then for the following 30 days.While both FBG and A1c drop in less than 1 month, the change in A1c was more rapid than the change if FBG.Possible reasons for the differences between FBG and A1c are presented.

Glucose is essential in providing the human body its’ energy needs.  Glucose relies upon the hormone, insulin, to enter our cells thereby producing the energy we need for everyday living.  However, while everyone needs a certain amount of glucose for daily energy production, excessive glucose is dangerously toxic to the body (primarily as a result of protein glycation). This leads to insulin resistance, caused by the glycation of insulin and insulin receptors, thereby resulting in high concentrations of glucose in the bloodstream [1]. The therapy for type 2 diabetes starts with attempts to control glucose through diet and exercise. If this fails, oral drugs are prescribed. 

If oral drugs do not work, insulin injections are used. Over 30% of people with type 2 diabetes are using insulin injections to control their blood glucose levels [2]. There is a vast literature documenting the role of nutraceuticals in the management of alterations in metabolism [3].

A new nutritional supplement, Lysulin, was recently introduced and is the only product that targets the cause on insulin resistance and diabetes. When a treatment change is made, patients are interested in how quickly they can observe a change in their FBG and A1c.  This information is only available for insulin injections, where the change in FBG can be seen in one day.  We examined the change in FBG and A1c in 20 subjects with Type 2 diabetes for 1 week prior to starting 3 daily servings of Lysulin and then continued testing for the following 30 days.  The results for all subjects are presented in Table 1.

As shown in the Table 1, 70% of participants saw a benefit (14 out of 20), 20% saw no change (4 folks) and 10% may have had an increase, although slight. The average change in FBG is shown in Figure 1.

As seen in Figure 1, the average FBG started dropping after 14 day and had started to level off after 27 days.  As shown in the Table 1,

65% of participants saw a benefit using Lysulin (13 out of 20), 25% (5 subjects) saw no change and 10% (2 subjects) may have had an increase of greater than 4 mg/dL glucose. The change in Average A1c is shown in Figure 2.

 Figure 1: Average Daily FBG (mg/dL) vs Day of Study.Figure 1: Average Daily FBG (mg/dL) vs Day of Study.

 Figure 2: Average A1c (%) vs Day of Study.Figure 2: Average A1c (%) vs Day of Study.

 Table 1: Change in FBG and A1c before and after Lysulin – 3 servings a day.Table 1: Change in FBG and A1c before and after Lysulin – 3 servings a day.

As seen in Figure 2, the A1c was lower at 15 days and continued to decrease at the day 31 test.  The reduction in A1c is statistically significant, with p=0.0004 at day 15, p=0.0002 at day 31.  As shown in the above table, 70% of participants saw a benefit using Lysulin (14 out of 20), and 20% saw no change, 4 subjects had no change (+ 0.2 %) and 10% may have had an increase, although slight. This is consistent with A1c drops seen in earlier Lysulin studies [4-6].  Interestingly, subject 20 had an A1c decrease of 9.8% to 9.2% but their FBG increased from 180 mg/dL to 187 mg/dL.

Of more importance is the observation that 70% of participants saw an improvement in their A1c.  There are several possible explanations why 100% did not see an improvement in their A1c.  The most obvious would be a lack of compliance in taking the recommended 3 servings a day of Lysulin or a change in diet, exercise or lifestyle which could also effect glucose levels.  Another possibility is that a certain percentage of the population does not effectively move the 3 primary ingredients in Lysulin from their gut into the bloodstream, due to microbiome population in the gut or other reasons that are ruled by genetics [7].

Another important finding was that A1c dropped more quickly than did the FBG.  This implies that the daily average glucose dropped faster than the FBG.  This finding has been reported by others–see which concluded that post-lunch and bedtime glucose showed relationships to HbA1c that were the most similar to 7 point glucose daily testing.  Fasting glucose correlated less well and results showed that with increasing HbA1c, fasting glucose progressively underestimated the HbA1c level. 

 Summary and Conclusion

This study compared the change in FBG and A1c following a change in treatment.  The results are that FBG changes can be observed in 2 to 3 weeks and changes in A1c can be observed in as little as 2 weeks.  This substantiates both the use of Lysulin for type 2 diabetes and the use of A1c to measure the effectiveness of changes in diabetes therapy [8].  


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5.       Burd JF, Noetzel V, Gonzalez A and Melero FAA. Lysulin®: A double-blind placebo controlled pilot study of daily oral supplementation in people with type 2 diabetes (2018) Diabetes Management 8: 154-162.

6.       Burd JF, Alvarez Malero FA, and Nortzel V. Hemoglobin A1c (HbA1c) shows improvement in glycemic control in as little as two weeks following the addition of Lysulin to the treatment of diabetes (2018) Diabetes Management 8: 82-84.

7.      Jafarnejad A, Bathaie SZ, Nakhjavani M, Hassan MZ and Banasadegh S. The improvement effect of L-Lys as a chemical chaperone on STZ-induced diabetic rats, protein structure and function (2018) Diabetes/Metabolism Research and Reviews 24: 64-73.

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*Corresponding author: John F Burd, Lysulin, Inc., 3525A Del Mar Heights Road, Suite 398, San Diego, California, USA, Tel: 619-992-2873, E-mail: 


Burd JF. Both fasting blood glucose (FBG) and A1C drop in less than one month after starting lysulin supplementation (2019) J Obesity and Diabetes 3: 33-35.


Lysulin, Type 2 diabetes, Glucose.