Polypharmacy is that the synchronous use of multiple medications by a patient. Polypharmacy is commonest within the older, touching concerning four-hundredth of older adults living in their own homes. Concerning twenty first of adults with intellectual incapacity are exposed to polypharmacy. Polypharmacy is not essentially imprudent, however in several instances will cause negative outcomes or poor treatment effectiveness, usually being a lot of harmful than useful or presenting an excessive amount of risk for deficient profit. Therefore, health professionals take into account it a scenario that needs watching and review to validate whether or not all of the medications area unit still necessary. Issues concerning polypharmacy embody magnified adverse drug reactions, drug interactions, prescribing cascade, and better prices. Polypharmacy is usually related to a diminished quality of life, including decreased mobility and cognition. The definition of polypharmacy continues to be debated. Definitions have ranged from two medications at a time to eighteen, or more of medications than clinically necessary. Five or more synchronous regular medications seem to be the foremost common definition. Despite the uncertainty around a definition, specialists typically agree on the magnitude, potential for damage and potential for reduction in medication regimens for older individuals. Journal accepts leading forefront original research papers, review manuscripts, case reports and commentary in the field. Our target audience, readers and contributors are worldwide. Pharmacoepidemiology Researches invites an article to publish in the Journal of Pharmacovigilance and Pharmacoepidemiology.