Donepezil is a medication used to treat Alzheimers disease. Common side effects include nausea, trouble sleeping, aggression, diarrhea, muscle cramps and feeling tired. Serious side effects may include heart arrythmias, urinary retention, and seizures. Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor.
Donepezil binds and reversibly inactivates the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This increases acetylcholine concentrations at cholinergic synapses