Neurophysiology and Rehabilitation



Editor in chief

Davide Vito Moretti
Professor of Neurophsyiology
Semmelweiss University
Neuroscientist at S.John of God
National Research Institute
Italy 

About Journal

Neurophysiology and Rehabilitation is an open access journal maintained by Edelweiss publications. The Journal emphasize in publishing the original scholarly articles related to Neurology and Rehabilitation worldwide. The journal follows rapid review process with the Eminent Editorial Board. Neurophysiology and Rehabilitation provides a global open access platform for the upcoming researchers to globalize their research.

Neurophysiology and Rehabilitation emphasize in publishing the original scholarly articles related to Neurology and Rehabilitation worldwide. The journal follows rapid review process with the Eminent Editorial Board.

Author may submit the manuscript related the below topics at neurophysiology@ewpsjournals.com

Neurophysiology is a branch of neuroscience and physiology concerned with the study and functioning of the nervous system it is also related to neuroanatomy, psychology, electrophysiology, and its applications in clinical neurophysiology. There are a few tools which are elementary to neurophysiological research, such as electrophysiological recordings which includes extracellular single-unit recording, patch clamps, and voltage clamps. Calcium imaging, molecular biology, ontogenetic, and also play a key role into neurophysiology.

Neurological rehabilitation branch of medicine which can generally reduce symptoms, improve function to the damage caused by infections, injuries, degenerative diseases, tumors, structural defects, and disorders in the circulatory system can be impairing the nervous system. Some of the conditions that have been benefited from neurological rehabilitation includes vascular disorders, functional disorders, neuromuscular disorders, degenerative disorders, like Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington chorea, Alzheimer disease.

Edelweiss Publication Inc is an open access journal which aims to publish most complete and genuine source of information in the form of short commentary, mini review, case report, related, but not limited to above areas and making them available freely through online without any subscriptions and restrictions to researches worldwide.

Neurophysiology and Rehabilitation publish Research, Review, Short commentary, Case Report, Mini Review related to but not limited to above areas. 

Neurology is the study of disorders related to Nervous system. Neurology deals with their diagnosis and treatment. Neurophysiology is the branch of neuroscience and the physiology of it. It mainly focuses on study related to the functioning of Nervous system. The neurophysiology is related to different neurosciences like, Electrophysiology, Psychology, Neurobiology, Cognitive science, neuro-anatomy and other Brain Sciences.

Rehabilitation is mainly the science which restores something that is damaged from its former condition. This rehabilitation is of different types, such as; Drug Rehabilitation, Occupational rehabilitation, Physical Therapy, Psychiatric rehabilitation, Physical medicine and Rehabilitation, neuropsychology and many more. Rehabilitation is mostly done for the people suffered with different neural disorders, which help them to move on with their life normally.

Scope of the Journal

Neurophysiology and Rehabilitation Journal publishes all the articles related to neurology, neurophysiology, neurological disorders and the rehabilitation accordingly. Neurophysiology and Rehabilitation covers the topics related to neurology and rehabilitation, which includes: Electrophysiology, Psychology, Neurobiology, Cognitive science, neuro-anatomy, Brain Sciences, Drug Rehabilitation, Occupational rehabilitation, Physical Therapy, Psychiatric rehabilitation, Physical medicine and Rehabilitation, neuropsychology, neurology, rehabilitation, neurorehabilitation, neurophysiology, neuropsychiatry, cerebral Ischemia, brain disorders, regenerative medicine, Cognition, Spinal Cord Injury.

Neurology is the study of the nervous system that deals with anatomy, functioning, and disorders of the nervous system. It includes about the diagnostic techniques, tools, and cure for diseases involving the central and peripheral nervous system. Understanding and functioning of the nervous system at the cellular or tissue level, and identifying specific genes and proteins involve in neurological diseases. Neurology research is aimed at developing and refining cures for neurological disorders.

Neuroscience (or neurobiology): it is a multidisciplinary branch of biology and it is a combination of anatomy, physiology, molecular biology, cytology, developmental biology, mathematical modeling and psychology, neural coding,psychoendoneuroimmunology (PENI) to understand the properties of neurons and neural circuits.

Psychoneuroimmunology (PNI) also referred to as psychoneuroendocrinoimmunology (PNEI), it is an interdisciplinary approach, including psychology, immunology, neuroscience, genetics physiology, pharmacology, psychiatry, behavioral medicine, molecular biology infectious diseases, rheumatology and endocrinology. All researches in PENI can be published with us at Neurophysiology and Rehabilitation journal. It is run by Edelweiss Publications Inc, USA.

Current research in Neurophysiology

Current research in Neuro rehabilitation

  • ·         Locomotor
  • ·         Behavioral Outcome and Neural Correlates.
  • ·         Bilateral Motor Cortex Plasticity
  • ·         Chronic Stroke

Editorial Board

The journal of Neurophysiology and Rehabilitation consist of editorial board members from all over the world who help us in rapid peer review process (4-6 weeks).

Hari Shanker Sharma Director, CNS Injury & Repair (IECNSIR, Neurobiology, Uppsala University, Uppsala, Sweden Sharma@surgsci.uu.se

WK Tang Professor Department of Psychiatry, Chinese University of Hong Kong, Hong Kong
tangwk@cuhk.edu.hk

Guodong Cao Associate Professor Department of Neurology, University of Pittsburgh, Pittsburgh, USA caogd@hotmail.com

Rabiul Ahasan Associate Professor, Faculty of Medicine and Health Sciences, Universiti Sultan Zainal Abidin, Malaysia arabiul@unisza.edu.my

For more editorials board members

Core Fields Covered

A neurological disorder is any disorder in the nervous system includes structural and electrical abnormalities in the brain and spinal cord. Some of the examples and symptoms include paralysis, loss of sensation muscle weakness, poor coordination, seizures, pain, confusion, and altered levels of consciousness. They may be determined by neurological examination and studies and treated within the specialties of neurology and clinical neuropsychology.

Neurological disorders are diseases of the brain, spine and the nerves that connect them. There are more than thousand diseases related to nervous system, such as brain tumors, epilepsy, and stroke front temporal dementia…...

Neurosurgery or neurological surgery, is the medical skill concerned with the, diagnosis, prevention, surgical treatment, and rehabilitation of disorders which affect any part of the nervous system including the spinal cord, brain, and extra-cranial cerebrovascular systemperipheral nerves.

Alzheimers disease-it is the more common type of theneurological disorder in which death of the brain cells, cognitive decline, and loss of memory. Where it involves the formation of plaques and tangles in the brain, Amyloid-beta is a key component of the brain plaques found during extent of Alzheimers disease. The Edelweiss publications welcome original manuscripts related to all neurological disorders and related aspects.

Symptoms includes reduced ability to remember information, Impairments to reasoning, Changes in behavior Personality the progression of Alzheimer in three main stages, preclinical, before symptoms appear, dementia, mild cognitive impairment. In some cases, genetic testing may be done. The people with APOE-e4 gene will have higher chances of getting this disease at the age of 55 years. By performing this test can indicate person having or developing the disease. The emerging biological tests make it possible to assess for biomarkers in people with the risk of Alzheimers. There is no known cure for Alzheimer. As the dead brain cell cannot be regenerated.

Parkinsons disease - Parkinsonism is a neurological syndrome characterized by rigidity, tremor, hyperkinesia, postural instability. A person with Parkinsons disease has untypically low dopamine levels dopaminergic neurons (types of nerve cells) in the substantianigra part of the brain will died (Dopamine-generating cells). A neurological syndrome usually emanate from deficiency of the neurotransmitter dopamine as the result of vascular degenerative and inflammatory changes in the basal ganglia. Although this disease is not leads to direct cause of death, it is a slow progressive disease, and symptoms get worse over time and it is chronic disease - a long-term disease and is incurable. No specific test exists to diagnose Parkinsons disease. Parkinsons disease based on medical history, signs and symptoms. A Single-Photon Emission by Computerized Tomography (SPECT) scan called a Dopamine Transporter (DAT) scan used to determine the Parkinsons disease.

Huntington chorea: It is a progressive neurodegenerative disorder and it is characterized by behavioral changes, mood disorders, cognitive impairments this disorder leads to death. It is a mutation of the HTT gene is called huntingin. This gene involve in the chemical signaling, transporting materials protecting the cell from apoptosis. It is a trinucleotide repeat mutation disorder, under normal conditions HTT gene has a CAG repeats. Under abnormal conditions CAG repeats increases significantly. These extra repeats results in gene abnormality in area of Exon 1 which resulted in elongated protein breaks in to smaller, toxic fragments binds and accumulate in neurons results in the abnormal functioning.

The Journal of Neurophysiology and Rehabilitation running by Edelweiss publications accepts all the research work, commentaries, review articles, case reports, many more articles related to Huntington chorea.

Brain and Spinal Tumors - are abnormal growths of tissue found inside the skull or the bony spinal column, which are the part of the central nervous system. Benign tumors are noncancerous that cant be completely removed may require treatment such as chemotherapy or radiation, and malignant tumors are cancerous grow quickly and spread to surrounding tissue and may return after treatment. Tumors that originate in the brain or spinal cord are called primary tumors. One of the noninvasive treatments with the noninvasive treatment with the Gamma Knife and Cyber Knife can treat tumors. Editorial board ensures a rapid peer review process helping Edelweiss Publications to run it successfully.

Central Cord Syndrome - is a form of incomplete spinal cord injury characterized by impairment in the arms and hands and to a lesser extent in the legs. The brains ability to send and receive signals to and from parts of the body below the site of injury is reduced but not entirely blocked. Symptoms may include paralysis or loss of fine control of movements in the arms and hands. Research related to central cord syndrome is invited by Neurophysiology and Rehabilitation journal.

Cerebellar Degeneration - is a disease progressive in neurons in the cerebellum that cause cerebellar degeneration and also interfere with the medulla oblongata, cerebral cortex, and the brain stem. Manuscripts related to cerebellar degeneration shall be published in Neurophysiology and Rehabilitation journal. You can submit us using the email id neuro@edelweisspublications.org

Encephalopathy-It is neuropsychiatric abnormalities in liver, dysfunction and other known brain disease. It is characterized by, intellectual impairment personality changes, and a depressed level of consciousness. More research done on encephalopathy is welcome, we shall publish research/review/case reports in Neurophysiology and Rehabilitation journal.

Therapies: Apart from the issue of a cure, patients with neurological disorders will be placed in rehabilitation. To restore the lost function, therapies for neurological disorders consist of Physiotherapy to manage the symptoms and restore some functions. Medication is taken to restore the function or prevent magnify of the patients condition. Cognitive behavioral therapy (CBT) focuses on reorientation of a patients behavior related to their disability, it has shown considerable effect in the treatment of ADHD and anxiety.

Current Articles

Neuropharmacological Evaluation of Methanolic Extract from Mercurialis Annua a Plant used in Moroccan Traditional Medicine

Author(s): Zouhra Doukkali*, Mohamed Amine Boumahdi, EL Houcine Bouidida, Khalid Taghzouti

Current therapeutic for the treatment of anxiety is associated with a wild variety of prominent side effects. The traditional use of plant extract to health care can indicate an important source of new pharmaceuticals. In Morocco traditional medicine, the use of Mercurialis annua is commonly recommended for relief of anxiety. Nevertheless, despite its popular use there are no studies related to its possible neuropharmacological effect.

Here, we investigated the possible anxiolytic effect of the extract of M.annua after acute treatment in mice. The methanolic extract from the aerial parts of M.annua (100, 200 or 400 mg/kg) was orally administered, and its anxiolytic effect was evaluated in hole board test, the light–dark box test, and motor coordination with the rota rod test. Diazepam was employed as standard drug 1mg/kg.

The methanolic extract of Ma 100 mg/kg increased the time spent in the brightly-lit chamber of the light/dark box, as well as in the number of times the animal crossed from one compartment to the other. Performance on the rota rod was unaffected. In the whole board test, the extract significantly increased head-dip counts. These results provides support for anxiolytic activity of Mercurialis annua, in line with its medicinal traditional use, and may also suggest a better side-effect profile of Mercurialis annua relative to diazepam. 

Insidious Cerebral Capillary Trauma from Motor Vehicle-Induced Vibration

Author(s): Prabhjot Grewal, Samita Goyal, Magdelana Matloub, FengYi Shen, Lin-ling Zhang, Hani S. Matloub, Robert Havlik, Ji-Geng Yan.

Cumulative cerebral injury from motor vehicle-induced whole body vibration has not been demonstrated thus far. Our lab has demonstrated isolated cerebral injury from whole body vibration and we believe that repetitive vibration can cause cumulative insults, impairing cerebral function. A simulated motor vehicle-induced whole body vibration study was conducted with fifty-six Sprague-Dawley rats divided into seven groups (N=8): (1) 8-week control group; (2) 8-week vibration group (exposed to whole body vibration at 30 Hz and 0.5g acceleration for 4 hours/day, 5 days/week for 8 weeks); (3) 8-week vibration group with preconditioning human apolipoprotein A-I molecule mimetic (4F); (4) 8-week vibration group with post conditioning 4F peptide; (5) 8-week vibration group with pre and post conditioning 4F peptide; (6) 12-week control group; and (7) 12-week vibration group (exposed to the same vibration, 5 days/week for 12 weeks). At the end point, all rats were evaluated by brain histo-pathological studies.

The pathology demonstrated capillary constriction with surrounding edema as well as thickened, uneven and damaged capillary walls. Capillary constriction reduces the oxygen supply to cerebral neurons, leading to neuronal damage. In the 12-week vibration group, each effect was more pronounced as compared to the 8-week vibration group. There was no prominent cerebral capillary damage in the 4F-peptide conditioning groups. This study showed cumulative cerebral injury from motor vehicle-induced whole body vibration and demonstrated the preventative effect of 4F-peptide conditioning.

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