Neuromelanin is a pigment present in the brain which is structurally related to melanin. It is a polymer of 5,6-dihydroxyindole monomers. It is believed to protect neurons in the substantia nigra from iron-induced oxidative stress. Neuromelanin is expressed in large quantities in catecholaminergic cells of the substantia nigra giving dark color to the structures. It is a type of melanin and similar to other forms of peripheral melanin. It is insoluble in organic compounds, and it can be labeled by silver stains. It is called neuromelanin because of its function and the color change that appears in tissues containing.
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