Edelweiss cancer Open Access is interested in publishing research, review manuscripts covering all aspects of cancer. We invite manuscripts which are novel and highly innovative in detecting or curing cancer of all forms. Clinical trial studies, research on new therapeutic agents, drugs and chemicals and new concepts for detection and treatment of cancer.

Edelweiss: Cancer Open Access

Editor in chief

Ashok Jain
Professor of Biology
Department of Natural and Forensic Sciences
Albany State University
USA

About Journal

Edelweiss cancer Open Access is interested in publishing research, review manuscripts covering all aspects of cancer. We invite manuscripts which are novel and highly innovative in detecting cancer of all forms. Clinical trial studies, research on new therapeutic agents, drugs and chemicals and new concepts for detection and treatment of cancer. It is an open access journal maintained by Edelweiss publications. The journal follows rapid review process with the Eminent Editorial Board. Edelweiss cancer Open Access provides a global open access platform for the upcoming researchers to globalize their research.

Author may submit the manuscript related the below topics at editor@edelweisspublications.com 

Edelweiss Cancer Open Access is a peer reviewed Journal, with rapid publication process. It covers the topics such as

Cancer research; MutationsCancer epidemiology and etiologyCancer genomics and proteomics

Oncology Cancer and radiation studiesCancer genetic pathways; Cell cycle control

Apoptosis; DNA Repair; Cancer and stem cellsCancer therapeutics

Drugs used in Cancer treatmentOncology Cancer and radiation studiesDNA Bridges; Prevention studies and education

Cancer cell biology; Melanoma; Non-coding RNACell Proliferation and not limited to above areas.

Cancer refers to the abnormal growth of cell tissue. Tumors are usually divided into benign and malignant. Malignant or cancerous tumours develop more rapidly. They are not localized and are often fatal for the patient. A benign tumour is localised, develops slowly and does not usually result in the patients death.

Oncology is the study of cancer and it deals with diagnosis and treatment of different types of cancers Brain tumors, melanoma, colorectal cancer, pancreatic cancer, hematological cancer and so on.

Edelweiss Publication Inc is an open access journal which aims to publish most complete and genuine source of information in the form of short commentary, mini review, case report, related, but not limited to above areas and making them available freely through online without any subscriptions and restrictions to researches worldwide.

Current key issues

Giloblastoma, Cancer Immunotherapy, TGF beta signaling in cancer, Triple Negative Breast, Cancers, new cancer therapies, myeloid innate immunity.

Editorial Board

The journal of cancer consists of Editorial Board members from all over the world who help us in rapid peer review process (4-6 weeks).

Mirko Diksic, Professor Emeritus, Department of Neurology and Neurosurgery,McGill University, Canada.

Mohammad Hosein Kalantar Motamedi, Professor,Trauma Research Center Baqiyatallah University of Medical Sciences, Iran.

Terry Lichtor, Clinical Professor New York Institute of Technology, USA.

 

For more editorials board members

Leukaemia

Leukaemia is a cancer in the blood forming tissues where cancer cells circulate in the body and behave like healthy cells and they imitate healthy cells, preventing their normal function. Carcinogenesis is a multistage process in which it causes damage to the genetic material and changes the cell from normal function to malignant.

Genetic Defects

Genes are located within the cell structures called chromosomes. Genes may undergo mutations and changes regulatory system of the cell which usually leads to abnormal function of the cell .A single genetic mutation will does not cause cancer.

The two types of cancer genes Oncogenes, are cancer generating genes, upon activation it causes distribution of cell tissue uncontrolled, regulation on the cells is lost. Other is Anti-cancer genes or Tumors suppressor genes can induce cancer due to the interruption/ ceases of their activity and causes damage to cell function. But the human immune system can be able to repair the damage. If immune system fail to work, damaged cells can start to divide uncontrollably and leading to carcinogenesis.

The majority of cancers are due to genetic mutations are inherited in some cases. Environmental causes were not inherited genetically such as pollution, tobacco, obesity, infections, radiations, stress. Exposure to particular substances has chances causing specific types of cancer. These substances are called carcinogens such as Tobacco smoke causes lung cancer, larynx, head, neck, stomach, bladder, esophagus and pancreas, kidney. The Edelweiss publications welcome original manuscripts related to all cancer and its related aspects.

Heredity

The majority of cancers are inherited mutations in the genes BRCA1 and BRCA2 with a more risk of breast cancer and ovarian cancer, and hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Editorial board ensures a rapid peer review process helping Edelweiss Publications to run it successfully.

 Infection

Oncoviruses includes human papillomavirus (cervical cancer), Epstein–Barr virus (B-cell lymphoproliferative disease and nasopharyngeal carcinoma), hepatitis B and hepatitis C viruses (hepatocellular carcinoma) and human T-cell leukemia virus-1 (T-cell leukemias) .

Bacterial infection also increases the risk of cancer, Helicobacter pylori-induced gastric carcinoma. Parasitic infections which induce cancer were Schistosoma haematobium (squamous cell carcinoma of the bladder) and liver flukes, Opisthorchis viverrini and Clonorchis sinensis (cholangiocarcinoma). Manuscripts related to cerebellar degeneration shall be published in cancer journal.

You can submit us using the email id: editor@edelweisspublications.com 

Radiation

Non-ionizing ultraviolet radiations causes non-melanoma skin cancers caused ultraviolet radiation, mostly from sunlight. Ionizing radiations include medical imaging and radon gas. Ionizing radiation is not a particularly strong mutagen but radiation is a more potent source of cancer when combined with other cancer causing agents such as radon, tobacco smoke and some more. More research done on Radiation induced cancer is welcome we shall publish research/review/case reports in cancer journal.

Hormones
some hormones play a role in the development of cancer by promoting cell proliferation Insulin growth factors and their binding proteins play a major role in cancer cell proliferation, differentiation and apoptosis. The field of oncology has three major areas surgical, medical and radiation. A surgical oncologist performs certain types of biopsies to help diagnose cancer and removes the tumor by surgery.

A medical oncologist treats cancer using chemotherapy and other medications, such as targeted immunotherapy. A radiation oncologist treats cancer using radiation therapy More research done on chemotherapy is welcome we shall publish research/review/case reports in cancer journal. A hematologist treats with blood cancers, such as leukemia, lymphoma, and myeloma. More research done on hematological malignancies is welcome we shall publish research/review/case reports in cancer journal.

Genome Editing Technology

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a family of DNA sequences in prokaryotes. It is one of the defense mechanism in prokaryotes, these sequences contains snippets of DNA are formed due to infection of viruses in bacteria and are used by the prokaryote to detect and destroy DNA from similar viruses during subsequent attacks and form the basis of a technology known as CRISPR/Cas9 that effectively and specifically changes genes within organisms. Spacer is a short segment of DNA from previous exposures to foreign DNA of a virus or plasmid. Small clusters of cas genes are located next to CRISPR sequences. The following approach is an immune therapy in which a patients own blood cells will be removed and genetically altered using these technology. The cancer treatment is designed to target myeloma, melanoma, and sarcomas. With the application of new gene editing technologies in this field has great potential to improve human health. With the Development of engineered site specific endonucleases like zinc finger nucleases (ZFNs), transcription activator like effector nucleases (TALENs), and CRISPR/Cas9 has been revolutionizing genetic approaches in biomedical research fields. These new tools have opened opportunities to carry out targeted genome editing without the need for manipulating embryonic stem cells availability. This approach saves time and cost. But CRISPR technology is considered far easier to use. The Edelweiss publications welcome original manuscripts related to all advance molecular genomic therapy on cancer biology and its related aspects.

Few of the Articles Published in our journal

Examining Chemotherapy-Related Cognitive Changes in Colorectal Cancer Patients: A Feasibility Trial

Author(s): Marie-Rose Dwek, Lorna Rixon, Alice Simon, Catherine Hurt, Stanton Newman

Introduction: Research suggests that chemotherapy may be related to decline in patients cognitive functions. Objectives: To assess the feasibility and acceptability of a multi-site study designed to examine the nature and extent of chemotherapy-related cognitive changes in colorectal cancer patients. Method: Data was collected over 8 months using objective and self-reported measures of cognitive functioning and self-reported quality of life, fatigue and mood questionnaires. The assessment battery was administered pre- and mid-chemotherapy treatment to a consecutive sample of colorectal cancer patients across three London-based NHS Trusts. Participants included patients who had undergone colorectal surgery and were scheduled to have adjuvant chemotherapy treatment, or no further cancer treatment.  Main outcome measures: Recruitment procedures, rate of recruitment, suitability of exclusion/inclusion criteria, acceptability of data collection procedures and the battery, and attrition rates. Results: From 1 April 2014 to 1 December 2014, 42 eligible participants were invited to take part in the trial. Of the 17 that completed pre-chemotherapy assessments, only 1 withdrew at follow-up due to reasons of ill health from disease recurrence. All participants completed the entire battery and indicated that they found the trial acceptable. Conclusions: What went wrong: Strained researcher resources; loss of eligible participants to competing studies, restrictive upper age limit. Possible solutions: Removal of upper age limit, an increased dedicated research team to increase rate of recruitment. The large multi-site study is feasible with suggested amendments and is acceptable to patients and medical teams. Acceptability of trial to medical teams is further evidenced by requests of collaboration from two additional London based NHS Trusts. Lessons learned: This feasibility trial provides evidence to other researchers designing similar studies in this area of an acceptable design and the need for appropriate funding for resources to recruit large enough consecutive samples of patients with solid tumour cancers.

 

The Utility of Visual Inspection with Acetic Acid in Cervical Cancer Screening

Author(s): Chidi Okorie Onwuka, Ima-Obong A. Ekanem

Objective: Cervical cancer is potentially preventable but still remains a leading cause of cancer mortality in in developing countries like Nigeria. Cytology-based screening programmes are difficult to maintain in these countries. Developing a cheap and reliable alternative is an important public health measure in these regions. This study was carried out to compare the utility of VIA and Pap smear as Cervical cancer screening methods in HIV-infected and non HIV-infected women. Methodology: Between March, 2013 and March, 2014, 461 consenting women, comprising 231 HIV positive women (HPW) and 230 HIV negative women (HNW) were recruited and screened for cervical cancer using conventional Pap smear and VIA simultaneously in University of Uyo Teaching Hospital. The Pap smear findings were classified using the 2001 Bethesda system. Patients with a positive Pap smear or abnormal VIA findings were recalled for biopsy. The results of the two tests were compared using biopsy as the gold standard. Results: The overall sensitivity, specificity, positive predictive value and negative predictive value for VIA were 100%,80%,76.9%, and 100%, respectively compared to 80%, 100%, 100%, and 88.2% for conventional Pap smear. Visual inspection of the cervix with acetic acid for cervical cancer screening is not specific but has a high negative predictive value. Conclusion: This study does not support a “see-and-treat” approach in cervical cancer management using VIA only. In resource-challenged areas, VIA can be applied on a large scale basis in primary screening for cervical cancer so as to triage, women who will benefit from further evaluation before applying the appropriate treatment.

 Immunotherapy of Prostate Cancer Patients could Overexpress The Virulence Factor Genes of E.faecalis

Author(s): Tayebe Talebzade, Fahimeh Baghbani-arani, Soha Sadeghi, Arvin Haghighatfard, Niloofar Ahmadi, Massoud Houshmand and Ali Dezhgir

Prostate cancer is the most prevalent and second cause of death from cancer in men worldwide. Immunotherapy is a new method for the treatment of several cancers that fights cancer cells by strengthening the immune system through some medications. While immunotherapy is a useful method for cancer treatment; its’ side effects still are not totally clarified. Numbers of prostate cancer patients which take immunotherapy are experiencing prostate inflammation and prostatitis after treatment period. Enterococcus Faecalis is Gram-positive and catalase-negative cocci that are common in the intestines of humans and other animals and cause most enterococcal infections such as intestinal infections, prostatitis, gastroenteritis and endocarditic. Present study aimed to evaluate the mRNA level of virulence genes which are involved in Enterococcus faecalis pathogenesis in prostate cancer patients that treated by immunotherapy. Expression level of gelatinase E (gelE) and Enterococcal surface protein (esp) genes were examined by Real time PCR in three groups of 68 male subjects. Group a normal subjects, group B prostate cancer patients before start treatment and group C prostate cancer patients after six months immunotherapy period. Results were showed significant (P<0.05) over expression of both genes (gelEand esp) in group against the group B. According to the results, it is reasonable that immunotherapy may have side effects such as increasing the pathogenicity risk of microflora in patients. Maybe these side effects could cause further infections after ending the immunotherapy of cancer. Antibiotic usage after or at the same time of immunotherapy period could prevent possible infections of microflora including E. faecalis.



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