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Huntington chorea is a progressive neurodegenerative disorder and it is characterized by behavioral changes, mood disorders, cognitive impairments this disorder leads to death. It is a mutation of the HTT gene is called huntingin. This gene involve in the chemical signaling, transporting materials protecting the cell from apoptosis. It is a trinucleotide repeat mutation disorder, under normal conditions HTT gene has a CAG repeats. Under abnormal conditions CAG repeats increases significantly. These extra repeats results in gene abnormality in area of Exon 1 which resulted in elongated protein breaks in to smaller, toxic fragments binds and accumulate in neurons results in the abnormal functioning.
