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Donepezil is a medication used to treat Alzheimers disease. Common side effects include nausea, trouble sleeping, aggression, diarrhea, muscle cramps and feeling tired. Serious side effects may include heart arrythmias, urinary retention, and seizures. Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor.
Donepezil should be used with caution in people with heart disease, cardiac conduction disturbances, chronic obstructive pulmonary disease, asthma, severe cardiac arrhythmias and sick sinus syndrome.
Donepezil binds and reversibly inactivates the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This increases acetylcholine concentrations at cholinergic synapses
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Related article links for Donepezil will appear here as matching content is published in Neurophysiology and Rehabilitation (ISSN: 2641-8991). Readers can also browse the journal archive and current issue for connected research.
