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Astrocyte-Neuron Interactions: Astrocytes are the predominant type of glial cell in the CNS. Glial especially astrocytes play a critical role in the central nervous system by affecting in various ways the neuronal single cell level interactions as well as connectivity and communication at the network level, both in the developing and mature brain. Astrocytes are also known to play an important role in many neurological disorders and neurodegenerative diseases. In relation to the key role of astrocyte-neuron interactions in synaptic physiology, accumulating evidence suggests that dysfunctions of neuron-astrocyte signaling may be linked to the pathology of various neurological and neurodegenerative diseases.
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